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Contraindicated (1)pentobarbital will reduce the level or impact of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Gals must not select estradiol valerate/dienogest as their contraceptive while utilizing sturdy CYP3A4 inducers as a consequence of possible reduce in contraceptive efficacy.pe